Butterbur is a perennial shrub with a 2,000-year history of traditional use. In the last twenty-five years, it has been trusted extensively throughout Europe by neurologists and other health professionals. Petadolex®, a patented form of butterbur extracted from the root and standardized to contain a minimum of 15% petasin and isopetasin, has been studied for healthy cranial vessel support. Petasin-containing extracts of butterbur may also help to maintain healthy histamine and cytokine release.